2019-nCoV穗蛋白中独特插入片段与HIV-1 gp120和Gag的相似性
https://www.biorxiv.org/content/10.1101/2020.01.30.927871v1
Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag
AbstractWe
are currently witnessing a major epidemic caused by the 2019 novel
coronavirus (2019- nCoV). The evolution of 2019-nCoV remains elusive.
We found 4 insertions in the spike glycoprotein (S) which are unique to
the 2019-nCoV and are not present in other coronaviruses. Importantly,
amino acid residues in all the 4 inserts have identity or similarity to
those in the HIV-1 gp120 or HIV-1 Gag. Interestingly, despite the
inserts being discontinuous on the primary amino acid sequence,
3D-modelling of the 2019-nCoV suggests that they converge to constitute
the receptor binding site. The finding of 4 unique inserts in the
2019-nCoV, all of which have identity /similarity to amino acid residues
in key structural proteins of HIV-1 is unlikely to be fortuitous in
nature. This work provides yet unknown insights on 2019-nCoV and sheds
light on the evolution and pathogenicity of this virus with important
implications for diagnosis of this virus. 6park.com 我们目前正在目睹由2019年新型冠状病毒(2019-nCoV)引起的主要流行病。 2019-nCoV的发展仍然难以捉摸。 我们在刺突糖蛋白(S)中发现了4个插入,这是2019-nCoV所独有的,在其他冠状病毒中不存在。 重要的是,所有4个插入片段中的氨基酸残基均与HIV-1 gp120或HIV-1 Gag中的氨基酸残基具有相同性或相似性。 有趣的是,尽管插入片段在一级氨基酸序列上是不连续的,但2019-nCoV的3D建模表明它们会聚在一起构成受体结合位点。 在2019-nCoV中发现4个独特的插入片段,这些插入片段都与HIV-1关键结构蛋白中的氨基酸残基具有同一性/相似性,这在自然界不太可能是偶然的。 这项工作提供了关于2019-nCoV的未知见解,并阐明了该病毒的进化和致病性,对诊断该病毒具有重要意义。
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